I hate to say this--to be the ONLY person I've seen so far to say this--but "meh."
I'm actually at that point of superhero exhaustion where the Avengers trailer does absolutely nothing for me aside from that bit of the Hulk saving Tony and Loki's snazzy new outfit. I never wanted to feel this way, but ugh, I just can't muster up anything close to enthusiasm for it. At this point, it feels like being excited for the next big event storyline, all hype and gimmick, which has almost certainly been overly-produced by committee until all life has been mushed out, just as Iron Man 2 was. There's too much at stake with this film for there to be much anything in the way of breathing space, creatively-speaking. And whatever there is will be coming from Joss Whedon, whose dialogue and creative bad habits I absolutely loathe.
In more intriguing-to-me news which will only be relevant to the more hardcore geeks amongst you:
God, he's so magnificently hubristacular. Also, I love that the format for the film is a TED Talk. I don't know why, but that touch makes me ridiculously happy.
That said, some people are taking Ridley Scott at his word that Weyland will be the one and only connection between Prometheus and Alien/Aliens (there are no other movies! None!). This is patently not true, considering that the also-awesome trailer clearly showed the same ship and "space jockey" room from the beginning of Alien. So either Ridley's gone Lucas-levels of delusional on us or--more likely--he's fibbin' to try and keep a few surprises secret.
I can't imagine that we won't see ONE glimpse of a Xenomorph, even something as small as an egg. But even still, I don't need that. I like that they're fleshing out the Weyland-Yutani Corporation in of itself. I think that'll add some nice extra enjoyment to the older movies.
Of course, the question now is whether nor not Aliens VS Predator is continuity, since Lance Henricksen played Mr. Weyland. People are already speculating that Lance and Guy could be uncle/nephew or something. I like the idea that Guy!Weyland designed the Bishops after his uncle. Of course, that would mean that he's the same guy who's in Alien³ WHICH DOESN'T EXIST LALALALA NEVER MIND.
And just to bring this back full circle, I feel it worth reminding the world that Joss Whedon wrote Alien Resurrection. While I love me some Marvel comics, I think I'll be putting all my intrigue on the side of Prometheus.
Never mind that Prometheus is being co-written by one of the main writers for Lost, so your own mileage may vary there. Hopefully Ridley's creative control with counteract any of Lindleof's bad habits.